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Grenoble's reputation for science is rendered all the more original by the fact that it was so long in the making. The Grenoble basin owes its development primarily to the very close ties forged between university research and industry, supported by the steadfast commitment of the local authorities. The presence today of major international facilities gives Grenoble a considerable edge over its European rivals. This publication recounts the great saga of Grenoble's scientific development, from the industrial revolution fuelled by hydropower and electricity to nanotechnology and its crossover into the field of biology.Par Michel Soutif.